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DiseaseDB
116 diseases, conditions, and pandemics. From ancient plagues to modern outbreaks, the complete history of human disease.
Deadliest in History
Bubonic Plague
The Black Death killed 75-200 million people in the 14th century, 30-60% of Europe. Plague doctors w...
Smallpox
Eradicated in 1980, the only human disease ever eliminated. Killed an estimated 300-500 million peop...
Spanish Flu
Infected 500 million people, one-third of the world population. Estimates of deaths range from about...
HIV/AIDS
Has killed over 40 million people since 1981. Originally called GRID, gay-related immune deficiency....
Malaria
Kills over 600,000 people annually, mostly African children under 5. Mentioned in ancient Chinese an...
COVID-19
First identified in Wuhan, China in December 2019. Declared a pandemic March 11, 2020. Over 770 mill...
By Category
Notable Pandemics
Athens Plague
Devastated Athens during the Peloponnesian War, killing 75,000-100,000. Thucydides survived and desc...
Antonine Plague
Brought back by Roman troops from Mesopotamia. Killed an estimated 5-10 million, possibly including ...
Bubonic Plague
The Black Death killed 75-200 million people in the 14th century, 30-60% of Europe. Plague doctors w...
Spanish Flu
Infected 500 million people, one-third of the world population. Estimates of deaths range from about...
COVID-19
First identified in Wuhan, China in December 2019. Declared a pandemic March 11, 2020. Over 770 mill...
Cholera
Seven major pandemics since 1817. John Snow traced the 1854 London outbreak to a single water pump, ...